2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

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Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Isoform Specific Products:

Phosphodiesterase (PDE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123210R
    Lodenafil (Standard)
    		Inhibitor
    Lodenafil (Standard) is the analytical standard of Lodenafil. This product is intended for research and analytical applications. Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
    Lodenafil (Standard)
  • HY-119708S
    Ensifentrine-d6
    		Inhibitor
    Ensifentrine-d6 (RPL-554-d6) is deuterium labeled Ensifentrine. Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activities. Ensifentrine can be used for chronic obstructive pulmonary disease (COPD) research.
    Ensifentrine-d<sub>6</sub>
  • HY-139095
    Cipamfylline
    		Inhibitor
    Cipamfylline is a PDE4 inhibitor that can cause PDE4A4 to accumulate in specific areas of the cell through interaction with the ubiquitin scaffolding protein p62. Cipamfylline can be used in the research of atopic dermatitis.
    Cipamfylline
  • HY-17464S2
    Cilostazol-d2
    		Inhibitor
    Cilostazol-d2 (OPC 13013-d2) is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM.
    Cilostazol-d<sub>2</sub>
  • HY-121491
    ONO-6126
    		Inhibitor
    ONO-6126 is a PDE4 inhibitor that can be used in research for asthma and chronic obstructive pulmonary disease.
    ONO-6126
  • HY-117605R
    N-Desmethyl Sildenafil (Standard)
    		Inhibitor
    N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.
    N-Desmethyl Sildenafil (Standard)
  • HY-113892
    Leniquinsin
    		Inhibitor
    Leniquinsin is a phosphodiesterase inhibitor, which is used as a vasodilator.
    Leniquinsin
  • HY-19393
    SCH 351591
    		Inhibitor
    SCH 351591 is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 58 nM. SCH 351591 can inhibit all 4 PDE4 subtypes (A, B, C, and D). SCH 351591 has the potential for the asthma and chronic obstructive pulmonary disease (COPD) research.
    SCH 351591
  • HY-69172
    RS-25344
    		Inhibitor
    RS-25344 is a selective inhibitor of phosphodiesterase type IV (PDE4). RS-25344 increases intracellular cAMP (cyclic adenosine phosphate) concentration by inhibiting PDE4 activity. RS-25344 can be used in the study of inflammation, immune diseases, neurodegenerative diseases and cardiovascular diseases.
    RS-25344
  • HY-110137R
    Furamidine dihydrochloride (Standard)
    		Inhibitor
    Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride). This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent.
    Furamidine dihydrochloride (Standard)
  • HY-131473
    Desmethyl thiosildenafil
    		Inhibitor
    Desmethyl thiosildenafil is a phosphodiesterase type 5 (PDE5) inhibitor[1].
    Desmethyl thiosildenafil
  • HY-18252S2
    Avanafil-d4
    		Inhibitor
    Avanafil-d4 (TA1790-d4) is deuterium-labeled Avanafil (HY-18252).
    Avanafil-d<sub>4</sub>
  • HY-123145
    JNJ-10258859
    		Inhibitor
    JNJ-10258859 is a potent and selective phosphodiesterase type 5 inhibitor, with a Ki of 0.23 nM. JNJ-10258859 can be used for erectile dysfunction research.
    JNJ-10258859
  • HY-N5012R
    Eurycomanone (Standard)
    		Inhibitor
    Eurycomanone (Standard) is the analytical standard of Eurycomanone. This product is intended for research and analytical applications. Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
    Eurycomanone (Standard)
  • HY-131824
    5,6-DM-cBIMP
    		Agonist
    5,6-DM-cBIMP, a cyclic nucleotide analog, is an agonist of PDE2 that can significantly enhance the cAMP and cGMP hydrolytic activities of PDE2[2.
    5,6-DM-cBIMP
  • HY-100990
    MMPX
    		Inhibitor
    MMPX is a potent PDE1 inhibitor.
    MMPX
  • HY-107022A
    BMS-341400 mesylate
    		Inhibitor
    BMS-341400 mesylate (Compound 6) is an orally active and a selective phosphodiesterase 5 (PDE5) inhibitor, with IC50 of 0.3 nM. BMS-341400 mesylate can be used for research of erectile dysfunction.
    BMS-341400 mesylate
  • HY-10469R
    GSK256066 (Standard)
    		Inhibitor
    GSK256066 (Standard) is the analytical standard of GSK256066. This product is intended for research and analytical applications. GSK256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK256066 is developed for the research of chronic obstructive pulmonary disease.
    GSK256066 (Standard)
  • HY-100640R
    Roflumilast Impurity E (Standard)
    		Inhibitor
    Roflumilast Impurity E (Standard) is the analytical standard of Roflumilast Impurity E. This product is intended for research and analytical applications. Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a agent which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM.
    Roflumilast Impurity E (Standard)
  • HY-16900R
    Rolipram (Standard)
    		Inhibitor
    Rolipram (Standard) is the analytical standard of Rolipram. This product is intended for research and analytical applications. Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
    Rolipram (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Phosphodiesterase (PDE) Isoform Comparison

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